Optimization Simulation of Ultrafine Dry Powder Blow-Assisted Pipe Based on CFD

Computational fluid dynamics (CFD) assisted performance evaluation of the Twincer™ disposable high-dose dry powder inhaler.

OBJECTIVES To use computational fluid dynamics (CFD) for evaluating and understanding the performance of the high-dose disposable Twincer™ dry powder inhaler, as well as to learn the effect of design modifications on dose entrainment, powder dispersion and retention behaviour. METHODS Comparison of predicted flow and particle behaviour from CFD computations with experimental data obtained wit...

Cfd Simulation Of Flow Field In An Inject Pipe Mixer

The Inject Pipe Mixer (IPM) are being used as venturi injectors and can also homogenize two fluids. The entry of secondary fluid as a jet influences flow field in the device. A CFD simulation of flow through an IPM (Lshape) has been carried out using ANSYS CFX 11.0 using water as the flowing fluid to understand the flow field under turbulent flow conditions using standard k--ε model. The result...

Optimization of the aerosolization properties of an inhalation dry powder based on selection of excipients.

The aim of this study was to investigate the influence of formulation excipients on physical characteristics of inhalation dry powders prepared by spray-drying. The excipients used were a series of amino acids (glycine, alanine, leucine, isoleucine), trehalose and dipalmitoylphosphatidylcholine (DPPC). The particle diameter and the powder density were assessed by laser diffraction and tap densi...

Study on Natural Ventilation Design Optimization Based on CFD Simulation for Green Buildings ¬リニ

Natural ventilation is crucial for conserving the energy, reducing carbon emission, and improving the comfort level of the built environment and the indoor air quality. The Computational Fluid Dynamics (CFD for short) represents the combination of the modern fluid dynamics, numerical mathematics and computer science. By employing CFD wind environment simulation technology, the architects are ab...

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